Selective fluorinating agents

Sep 28, 2007 · Fluorine substituents have become a widespread and important drug component, their introduction facilitated by the development of safe and selective fluorinating agents. Organofluorine affects nearly all physical and adsorption, distribution, metabolism, and excretion properties of a lead compound. A decarboxylative fluorination of tertiary β-keto carboxylic acids using an electrophilic fluorinating reagent proceeded in the absence of a catalyst or base to yield the corresponding α-fluoroketones very good yields. M. Katada, K. Kitahara, S. Iwasa, K. Shibatomi, Synlett, 2018, 29, 2408-2411. Alexander James Cresswell was born in Bradford in West Yorkshire, England, in 1985. He obtained his M.Chem. from the University of Oxford in 2008 and his D.Phil. in 2012 working in the group of Professor Stephen G. Davies on stereoselective fluorination with boron fluorides. 4-Iodotoluene difluoride (Tol-IF 2) is easy to handle and less toxic than many fluorinating agents. Selective monofluorination of b-keto esters, b-keto amides, and b-diketones takes place under mild conditions without the use of HF–amine complexes. 1 A new methodology for the synthesis of fluorinated cyclic ethers was recently reported, which utilized Tol-IF 2 to achieve a fluorinative ring-expansion of four-, five-, and six-membered rings. 2 When one equivalent of Tol-IF 2 is reacted with ... Studies are carried out on the superacid- catalyzed oxidative condensation of methane to higher hydrocarbons, as well as the selective, electrophilic catalytic conversion of methane to its monosubstituted derivatives including methyl halides and methyl alcohol.